Dental Technician Int'l Meeting as part of the CAD/CAM Digital & Oral Facial Aesthetics 37th Int’l Dental ConfEx / The future of regenerative dentistry: “Cells alone are not proving to be enough to provide lasting, curative treatments”
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DTMEA_No.2. Vol.14_LT.indd
PUBLISHED IN DUBAI
www.dental-tribune.me
Vol. 14, No. 2
Dental Technician Int'l Meeting as part
of the CAD/CAM Digital & Oral Facial
th
Aesthetics 37 Int’l Dental ConfEx
By CAPP Events & Training
Dental Technician International
Meeting (DTIM) has established a
tradition over the past years, gathering professionals dedicated to advancing dental technology. This year
again, DTIM is part of the CAD/CAM
Digital & Oral Facial Aesthetics 37th
Int’l Dental ConfEx, forming a pivotal
part of the event held at the prestigious Madinat Jumeirah Arena &
Conference Center n Dubai, UAE on
15-16 November 2024.
AD
Kicking off on Friday, 15 November, DTIM sets the stage with Round
Table Trainings designed to enrich
participants' knowledge and skills.
These sessions, hosted in the
pre-function area, feature a diverse
lineup of international speakers,
each covering specialized topics relevant to the field. With sessions repeated four times daily, attendees
have the flexibility to customize their
schedule, attending up to four sessions per day based on their preferences.
Whether your expertise lies in
crown and bridge, orthodontics, implantology, or prosthetics, DTIM
promises invaluable insights and
practical learning opportunities.
With trainings conducted in smaller
groups (with a maximum of 10 seats
available, plus additional standing
room), attendees can engage directly with presenters, seeking immediate answers to their queries and
benefiting from personalized guidance. The practical demonstrations
not only inspire but also equip at-
tendees with troubleshooting techniques, ensuring they leave with actionable knowledge.
•
•
•
•
•
•
•
Who should attend?
Dental Technicians
Prosthodontists
Orthodontists
Denturists
Maxillofacial Prosthetists
Dental Laboratory Owners
Students in Dental Technology
Embark on a journey of discovery
and innovation at DTIM within CAD/
CAM Digital & Oral Facial Aesthetics
37th Int’l Dental ConfEx, where the
forefront of dental technology
awaits.
For more information, visit the event website at www.cappmea.com/dtim-2024.
[2] =>
DTMEA_No.2. Vol.14_LT.indd
INTERVIEW
B2
Lab Tribune Middle East & Africa Edition | 02/2024
The future of regenerative dentistry:
“Cells alone are not proving to be enough
to provide lasting, curative treatments”
An interview with Dr Caralynn Collens
CMFlex, the first 3D-printed regenerative bone graft cleared by the FDA, is a ready-to-use flexible and off-the-shelf solution for use in periodontal or oral and maxillofacial surgery. (Images: © Dimension Inx)
By Anisha Hall Hoppe, Dental
Tribune International
Being able to not only customise
treatment plans but provide bioidentical implants to patients is a
dream that may not be too far off
considering the technology biomaterials platform Dimension Inx has
built to create therapeutic products
that enable an entirely new approach
to tissue regeneration. To learn more
about the potential of bioprinting,
Dental Tribune International reached
out to cofounder and CEO
Dr Caralynn Collens about the company’s first product for dental application and the future of custom
printed tissues.
Dr Collens, for our clinicians
who have never even heard of bioprinting, could you share a bit
about its purpose in medicine and
what Dimension Inx seeks to accomplish in the field?
Bioprinting traditionally refers to
a form of additive manufacturing
that combines 3D printing with cells,
growth factors and/or other biomaterials instead of conventional metals and plastics to create structures
that imitate natural tissues of the
body. These structures can advance
various medical applications, including 3D cell culture research, drug discovery and development, and regenerative medicine, including dental and periodontal applications.
Contrary to this traditional approach to bioprinting, Dimension Inx
was created to design, develop and
manufacture therapeutic products
that restore tissue and organ function without the requirement of cell
in corporation into the printing process. Our material-centric approach
generates novel biomaterials that
leverage the body’s natural ability to
restore and establish functionality to
address a variety of clinical applications.
Furthermore, our entire printing
process is performed at room temperature, creating acellular structures that are easy to ship and store
and enable off-the-shelf, readyto-use products.
How has the biomaterials field
changed in the last decade? What
does Dimension Inx hope to
achieve within the next ten years?
The traditional view of biomaterials focuses primarily on a material’s
capacity to provide physical support
and enable passive tissue growth.
Over the past ten years, however, this
mentality has shifted towards creating biomaterials that positively interact with their surrounding environment to promote new, healthy tissue
formation. Many such efforts rely on
physically and/or chemically modifying the surfaces of materials produced using established manufacturing methods. This approach can
generate products with improved
performance compared with their
bio-inert counterparts, but it cannot
unlock their full regenerative potential. To achieve this end, you must engineer biomaterial compositions
that better emulate native tissue
structure to produce biologically relevant microenvironments. We employ our proprietary processes to
create novel biomaterials with
unique, physiologically relevant microstructures that offer a 3D blueprint to direct cells to behave as intended. Products printed with our
platform enable a broad range of
therapeutic applications. Over the
next ten years, we expect to leverage
our unique capabilities and establish
ourselves as a market leader of innovative engineered tissue therapeu-
tics for a large range of indications
with significant clinical need, including Type 1 diabetes and fertility preservation.
What Dimension Inx projects
could apply to dentistry, and why
should a dental clinician or researcher look into your company?
We recently received US Food
and Drug Administration (FDA)
510(k) clearance for CMFlex, the first
3D-printed regenerative bone grafting product cleared by the FDA. As a
ready-to-use flexible ceramic for use
in periodontal, oral and maxillofacial
surgery, CMFlex offers a unique alternative to the current standard
practices of dental bone grafting,
such as autograft, allograft and xenograft. It is a synthetic material primarily composed of hydroxyapatite,
a natural mineral found in bones and
widely used in medical devices.
CMFlex is a safe and effective option for bone grafting, as it eliminates the need for painful and invasive procedures like autograft, which
involves harvesting bone from another part of the patient’s body, and
is then shaped and sized by the clinician to match the defect site. Additionally, unlike allograft and xenograft, CMFlex does not contain any
animal or human components, eliminating the risk of disease transmission. Its distinctive microstructure is
designed for high absorbency, rapid
vascularisation, angiogenesis and
tissue integration. Although CMFlex
is currently approved for human use
only in the US, dental clinicians and
researchers interested in utilising advanced synthetic biomaterials in
their practice should explore its benefits.
How did you get started in the
field, and what advice would you
offer to an organisation or clinician who would like to explore the
potential of biomaterials?
Prior to Dimension Inx, I had
operated in the advanced manufacturing space for several years. I
was the chair of the board of directors and senior adviser to the US
National Digital Manufacturing Institute, named MxD (Manufacturing x Digital). MxD was launched as
an independent organisation in
early 2019, originating from UI
Labs, where I served as CEO and
board director from 2014 to 2019.
However, it wasn’t until I joined Dimension Inx as CEO in 2019 to build
and advance its therapeutic portfolio that I explicitly entered the bioprinting arena. I was particularly
impressed by the company’s material- centric approach to designing
novel biomaterials and therapeutic
products that can be easily adapted
to address a variety of clinical applications.
Furthermore, Dimension Inx’s
patented platform enables us to
develop unique solutions that have
the right mix of characteristics to
optimise bio-functionality without
sacrificing usability or manufacturability.
Any organisation or clinician interested in further exploring the
potential of biomaterials should
contact us. CMFlex may already
meet their needs. In any case, we’d
love to learn more about their interests to see if we could be helpful.
Is there anything else you
would like to share with our readers?
There is a growing realisation in
the field of cell and gene therapy
that cells alone are not proving to
be enough to provide lasting, curative treatments. The local cell envi-
ronment, or micro environment,
plays an essential role in cellular
behaviour and, in the case of therapeutic approaches, therapeutic
efficacy. Biomaterial-based approaches can be used to create implantable microenvironments for
cell-based therapies that allow us
to replace or repair damaged biological functions inside of the
human body in a way not previously possible.
Editorial note: More information can be
found at www.dimensioninx.com.
This interview was published in 3D
printing—international magazine of
dental printing technology, Vol. 3, issue
2/2023.
Dr
Caralynn
Collens is passionate about
building teams
and organisations that harness technology to drive transformational change and improve the quality of people’s
lives. After starting her first company
while a joint MD and MBA student at
the University of Illinois Chicago in the
US, she spent her early career in venture capital and corporate finance, primarily focused on technology-based
university spinoffs. Prior to her current
position as CEO of Dimension Inx, she
was co-founder and CEO of UI Labs,
a first-of-its-kind technology organisation focused on the digital future of
industries. She earned her BS with honours from Northwestern University in
Evanston in Illinois.
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