Hygiene Tribune Middle East & Africa No.2, 2023
Novel adhesive patch helps treat oral lichen planus and recurrent aphthous stomatitis / Simple, pain-free technology for remineralising early carious lesions
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DTMEA_No.2. Vol.13_HT.indd
PUBLISHED IN DUBAI
www.dental-tribune.me
Vol. 13, No. 2
Novel adhesive patch helps treat oral
lichen planus and recurrent aphthous
stomatitis
By Dental Tribune International
BOSTON, US: Oral lichen planus
and recurrent aphthous stomatitis
are common chronic inflammatory
conditions that can affect patients’
quality of life. Since current treatment approaches are mainly palliative and often ineffective owing to
insufficient contact time of the
therapeutic agent with the lesions,
researchers have recently developed an adhesive patch to improve
retention in the oral cavity and enable sustained release of clobetasol-17-propionate, the firstline drug for treating both conditions.
In the study, the researchers—
from the Harvard School of Dental
Medicine in Boston—also examined the properties of the novel
bio-inspired adhesive patch, called
Dental Tough Adhesive (DenTAl),
regarding adhesion to diverse oral
tissues. They subjected DenTAl to
ex vivo mechanical testing, assessed its biocompatibility in vitro
and adhesion in vivo and ex vivo,
and investigated its drug release
in vitro when loaded with clobetasol.
They found that DenTAl has superior physical, such as stretchabil-
ity, and adhesive properties compared with existing oral technologies and is capable of strong adhesion to different kinds of wet and
dynamic intra-oral tissue. They also
reported that the clobetasol was
released in a tunable sustained
manner for up to four weeks and
demonstrated immunomodulatory
capabilities in vitro, resulting in reductions in several pro-inflammatory cytokines.
The study’s findings suggest
that DenTAl may be a promising
device for the intra-oral delivery of
small-molecule drugs for the management of painful oral lesions associated with chronic inflammatory
conditions such as oral lichen planus and recurrent aphthous stomatitis. The researchers said that future clinical applications may include delivery of antimicrobial and
chemotherapeutic agents to treat
periodontitis and precancerous or
malignant lesions.
The study, titled “Tough adhesive hydrogel for intraoral adhesion
and drug delivery”, was published
online on 8 March 2023 in the Journal of Dental Research, ahead of inclusion in an issue.
A newly developed adhesive patch has been shown to have robust adhesion to different kinds of wet and moving intra-oral
tissue. (Image: LTim/Shutterstock)
Join Dental Hygienist Seminar in Dubai
By CAPP Events & Training
DUBAI, UAE: Join the celebration of excellence in dental hygiene
at the upcoming Dental Hygienist
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The DHS offers cutting-edge,
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turing the latest products and technologies in oral healthcare. This is
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For more information
www.cappmea.com/conf-ex.
visit
[2] =>
DTMEA_No.2. Vol.13_HT.indd
HYGIENE TRIBUNE
E2
Hygiene Tribune Middle East & Africa Edition | 02/2023
Simple, pain-free technology for
remineralising early carious lesions
By Dental Tribune International
Swiss dentists and sisters Drs
Haleh and Golnar Abivardi are internationally renowned innovators,
award-winning serial entrepreneurs and the CEOs and founders
of vVARDIS, a Swiss manufacturer
of daily oral care and whitening
products, among others.
With the opening of your
first clinics in 2003, you were the
first in Switzerland to start a
dental service organisation.
Could you please tell us about
the launch of your business?
Golnar: Yes, we were just doing
what our heart told us to do without quite realising that we were
building a dental service organisation. However, before that, we had
run a public paediatric dental clinic.
In Switzerland, these clinics are
linked to primary schools for prevention, and thousands of children
are treated through them, many of
whom come from underserved
communities and underprivileged
backgrounds. As dentists and
mothers, it was painful to see our
patients suffering from general
health issues as well as psychological issues due to poor oral health,
caused by a lack of knowledge and
awareness and often dental fear.
Haleh: That’s why about
20 years ago, we had the idea of
launching the first fear-free chain
of dental clinics with a completely
new concept: open 365 days a year
from 7 a.m. to 9 p.m. for walk-in
and with the same corporate identity and design. The clinics looked
more like a spa than a dental office.
How did you come up with
the idea of founding vVARDIS?
Golnar: We founded vVARDIS
about three years ago, but our vision and foundational work for
vVARDIS started almost 20 years
ago, treating children with poor
oral health and treating homeless
adults. Our goal has always been to
practise preventive care rather than
restorative dentistry.
Haleh: This is also the reason
that, in addition to our clinics, we
ran our own dental hygienist school
with its own research centre, at
which we conducted clinical studies. Over ten years ago, we stumbled on the revolutionary technology of Curodont Repair, a painfree, non-invasive treatment for
early caries without the need for
anaesthesia or drilling that does
not stain or have a bad taste.
How does this technology
work?
Golnar: Enamel is the only dead
tissue in our body without living
cells, so it cannot regenerate itself.
The basis of the vVARDIS technologies is molecules made up of natural amino acids. With simple, painfree application, the vVARDIS products diffuse into the enamel to the
depth of the early carious lesion
and regenerate the enamel, unlike
other products, such as fluoride,
which only acts on the surface.
Which advantages are there
for dentists in adding vVARDIS
products to their care repertoire?
Haleh: About 85% of the patients have initial lesions, and only
5% of them receive treatment. In
the past, we had no way of treating
small lesions without removing a
lot of healthy hard tissue. As a dentist, I remember always being in a
dilemma, knowing that if the patient didn’t come back or came
back too late, not only could he or
she lose the tooth, but severe disease could result.
Golnar: The conventional approach to treating early carious lesions is either drilling or monitoring. With Curodont Repair, dental
professionals now have another
option for remineralising the lesions without removing healthy
dental tissue. The treatment per lesion takes about 5 minutes, saving
the dentist chair time and enabling
him or her to concentrate on treatments that are more challenging.
Even the dental hygienist can treat
the patient, which increases productivity.
The CEOs and founders of vVARDIS: Drs Golnar and Haleh Abivardi. (Image: Robert Strehler)
What is the next step for
vVARDIS?
Golnar: Some populations have
only limited or no access to dental
care. A product like Curodont Repair that is easy to use could be
made available for underserved
communities.
Editorial Note: More information
about vVARDIS can be found at
www.vvardis.com.
VVARDIS develops oral care products that rejuvenate tooth enamel. (Image: Dental Tribune International)
“We founded vVARDIS about three years ago, but our
vision and foundational work for vVARDIS started almost
20 years ago”— Dr Golnar Abivardi
[3] =>
DTMEA_No.2. Vol.13_HT.indd
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[4] =>
DTMEA_No.2. Vol.13_HT.indd
HYGIENE TRIBUNE
Hygiene Tribune Middle East & Africa Edition | 02/2023
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